CAR-T Cell Therapy (Chimeric Antigen Receptor T cell therapy) is an advanced immunotherapy that involves reprogramming a patient’s own T cells to recognize and attack cancer or trouble cells. The T cells taken from the patient’s blood are engineered to express chimeric antigen receptors (CARs) on their surface. These CARs help the T cells recognize specific targets, like […]
Recent studies reveal that NS3 functions as an RNA translocase, actively transporting RNA across cellular membranes. It achieves the movement by coupling ATP hydrolysis-providing the energy required for RNA transport. Across membrane invasion initiates the norovirus replication cycle including steps like RNA replication and the assembly of new viral particles. Targeting NS3 could interrupt the […]
Today, the U.S. Food and Drug Administration (FDA) approved lenacapavir for the prevention of HIV—ushering in a new era in viral prevention. Developed by Gilead Sciences, this long-acting therapy requires just two injections per year and provides near-complete protection against HIV infection. Lenacapavir works by targeting the HIV capsid proteins, which play a crucial role […]
Bispecific antibodies (bsAbs) provide novel mechanisms of action and therapeutic possibilities beyond those achievable with conventional IgG-based antibodies. Their development has accelerated over the past decade, leading to the approval of 14 bsAbs by the end of 2023—11 for oncology indications and 3 for non-oncology uses. These molecules come in various formats, target a wide […]
This study in eLife highlights that YAP, a protein linked to cancer therapy resistance, behaves differently depending on how cancer cells are cultured. In non-small cell lung cancer (NSCLC) with EGFR or KRAS mutations, resistance to targeted therapies is common. The research shows that acute resistance to EGFR/KRAS/BRAF inhibition is highly dependent on spatial and […]
Leptomeningeal metastasis—a deadly spread of solid tumors to the cerebrospinal-fluid-filled membranes around the brain and spinal cord—is characterized by strong immune infiltration and high levels of interferon-gamma (IFNγ). Researchers developed mouse models of lung cancer, breast cancer, and melanoma with leptomeningeal metastasis and found that mice lacking IFNγ or its receptor couldn’t control tumor growth. […]
MinneBio proudly presents its highly anticipated “Workshop on Enzyme Engineering and Applications,” a comprehensive event designed to delve into the intricate world of enzyme technology. Enzymes, the molecular workhorses of life, play a pivotal role in various industries, from pharmaceuticals to renewable energy. This workshop serves as a platform for researchers, scientists, and industry professionals to explore the latest advancements, practical applications, and future prospects of enzyme engineering.
